In vivo evaluation of [¹¹C]preladenant positron emission tomography for quantification of adenosine A_2A receptors in the rat brain.

ABSTRACT: [¹¹C]Preladenant was developed as a novel adenosine A_2A receptor positron emission tomography radioligand. The present study aims to evaluate the suitability of [¹¹C]preladenant positron emission tomography for the quantification of striatal A_2A receptor density and the assessment of striatal A_2A receptor occupancy by KW-6002. Sixty- or ninety-minute dynamic positron emission tomography imaging was performed on rats. Tracer kinetics was quantified by the two-tissue compartment model, Logan graphical analysis and several reference tissue-based models. Test-retest reproducibility was assessed by repeated imaging on two consecutive days. Two-tissue compartment model and Logan plot estimated comparable distribution volume ( V_T)

SUBMITTER: Zhou X 

PROVIDER: S-EPMC5381452 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature