In vivo evidence for long-term vascular remodeling resulting from chronic cerebral hypoperfusion in mice.

ABSTRACT: We have characterized both acute and long-term vascular and metabolic effects of unilateral common carotid artery occlusion in mice by in vivo magnetic resonance imaging and positron emission tomography. This common carotid artery occlusion model induces chronic cerebral hypoperfusion and is therefore relevant to both preclinical stroke studies, where it serves as a control condition for a commonly used mouse model of ischemic stroke, and neurodegeneration, as chronic hypoperfusion is causative to cognitive decline. By using perfusion magnetic resonance imaging, we demonstrate that under isoflurane anesthesia, cerebral perfusion levels recover gradually over one month. This recovery is paralleled by an increase in lumen diameter and altered tortuosity of the contralateral internal carotid

SUBMITTER: Struys T 

PROVIDER: S-EPMC5381461 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature