Pathways through which asthma risk factors contribute to asthma severity in inner-city children.

ABSTRACT:

Background

Pathway analyses can be used to determine how host and environmental factors contribute to asthma severity.

Objective

To investigate pathways explaining asthma severity in inner-city children.

Methods

On the basis of medical evidence in the published literature, we developed a conceptual model to describe how 8 risk-factor domains (allergen sensitization, allergic inflammation, pulmonary physiology, stress, obesity, vitamin D, environmental tobacco smoke [ETS] exposure, and rhinitis severity) are linked to asthma severity. To estimate the relative magnitude and significance of hypothesized relationships among these domains and asthma severity, we applied a causal network analysis to test our model in an Inner-City Asthma Consortium study. Participants compr

SUBMITTER: Liu AH 

PROVIDER: S-EPMC5381517 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature