Phylogenomic Insights into Mouse Evolution Using a Pseudoreference Approach.

ABSTRACT: Comparative genomic studies are now possible across a broad range of evolutionary timescales, but the generation and analysis of genomic data across many different species still present a number of challenges. The most sophisticated genotyping and down-stream analytical frameworks are still predominantly based on comparisons to high-quality reference genomes. However, established genomic resources are often limited within a given group of species, necessitating comparisons to divergent reference genomes that could restrict or bias comparisons across a phylogenetic sample. Here, we develop a scalable pseudoreference approach to iteratively incorporate sample-specific variation into a genome reference and reduce the effects of systematic mapping bias in downstream analyses. To characterize t

SUBMITTER: Sarver BA 

PROVIDER: S-EPMC5381554 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature