Cross-Species Genome-Wide Identification of Evolutionary Conserved MicroProteins.

ABSTRACT: MicroProteins are small single-domain proteins that act by engaging their targets into different, sometimes nonproductive protein complexes. In order to identify novel microProteins in any sequenced genome of interest, we have developed miPFinder, a program that identifies and classifies potential microProteins. In the past years, several microProteins have been discovered in plants where they are mainly involved in the regulation of development by fine-tuning transcription factor activities. The miPFinder algorithm identifies all up to date known plant microProteins and extends the microProtein concept beyond transcription factors to other protein families. Here, we reveal potential microProtein candidates in several plant and animal reference genomes. A large number of these microProtein

SUBMITTER: Straub D 

PROVIDER: S-EPMC5381583 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature