Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants.

ABSTRACT:

Aims

Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there are limited data on whether having more than one of these conditions is associated with additive effects. We aimed to quantify the magnitude of their associations with non-demented cognitive abilities and determine the extent to which these associations were additive.

Methods and results

We examined cognitive test scores in domains of reasoning, information processing speed and memory, included as part of the baseline UK Biobank cohort assessment (N = 474 129 with relevant data), adjusting for a range of potentially confounding variables. The presence of hypertension, CAD and diabetes generally associated with poorer cognitive

SUBMITTER: Lyall DM 

PROVIDER: S-EPMC5381595 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature