Bridging Chromosomal Architecture and Pathophysiology of Streptococcus pneumoniae.

ABSTRACT: The chromosome of Streptococcus pneumoniae is organized into topological domains based on its transcriptional response to DNA relaxation: Up-regulated (UP), down-regulated (DOWN), nonregulated (NR), and AT-rich. In the present work, NR genes found to have highly conserved chromosomal locations (17% of the genome) were categorized as members of position-conserved nonregulated (pcNR) domains, while NR genes with a variable position (36% of the genome) were classified as members of position-variable nonregulated (pvNR) domains. On average, pcNR domains showed high transcription rates, optimized codon usage, and were found to contain only a small number of RUP/BOX/SPLICE repeats. They were also poor in exogenous genes but enriched in leading strand genes that code for proteins involved in prim

SUBMITTER: Martin-Galiano AJ 

PROVIDER: S-EPMC5381641 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature