Potential and clinical translation of oncolytic measles viruses.

ABSTRACT:

Introduction

Oncolytic viruses represent a novel treatment modality that is unencumbered by the standard resistance mechanisms limiting the therapeutic efficacy of conventional antineoplastic agents. Attenuated engineered measles virus strains derived from the Edmonston vaccine lineage have undergone extensive preclinical evaluation with significant antitumor activity observed in a broad range of preclinical tumoral models. These have laid the foundation for several clinical trials in both solid and hematologic malignancies, which have demonstrated safety, biologic activity and the ability to elicit antitumor immune responses. Areas covered: This review examines the published preclinical data which supported the clinical translation of this therapeutic platform, reviews the availab

SUBMITTER: Robinson S 

PROVIDER: S-EPMC5381660 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature