Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis.

ABSTRACT: The cluster of differentiation 24 (CD24) Ala57Val polymorphism has been implicated as a risk factor for multiple sclerosis (MS) and systemic lupus erythematosus (SLE); however, genetic studies have produced controversial results. A meta-analysis was performed on this topic. We used odds ratio (OR) and 95% confidence interval (95% CI) to investigate the strength of association. Eleven studies from nine publications consisting of 2466 cases and 2650 controls were included. The results suggested that the CD24 Val/Val genotypes were associated with an increased risk of MS in all study subjects and Caucasians (OR = 2.28, 95% CI: 1.68-3.10, Pz < 0.001 and OR = 2.30, 95% CI: 1.66-3.20, Pz < 0.001, respectively). Sensitivity analysis showed that no individual study was found to be significantly bi

SUBMITTER: Huang J 

PROVIDER: S-EPMC5381688 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature