X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.

ABSTRACT: The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

SUBMITTER: Yang H 

PROVIDER: S-EPMC5381722 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature