Genetic and neural predictors of behavioral weight loss treatment: A preliminary study.

ABSTRACT:

Objective

To examine neural mechanisms of action in behavioral weight loss treatment (BWL) and explore neural and genetic predictors of BWL.

Methods

Neural activation to milkshake receipt and genetics were compared in 17 women with obesity who received 12 weeks of BWL and 17 women who received no intervention. Participants were scanned twice using functional magnetic resonance imaging at baseline and 12 weeks. Weight was assessed at baseline, 12, 36, and 60 weeks.

Results

BWL participants lost more weight than controls at 12 weeks (-4.82% versus -0.70%). After 12 weeks, BWL had greater reduction in right caudate activation response to milk shake receipt than did controls. Among BWL participants, baseline to 12-week reduction in frontostriatal activation to milk shake

SUBMITTER: Chen EY 

PROVIDER: S-EPMC5381816 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature