Cost-effectiveness of dengue vaccination in Yucatan, Mexico using a dynamic dengue transmission model.

ABSTRACT:

Background

The incidence of dengue fever (DF) is steadily increasing in Mexico, burdening health systems with consequent morbidities and mortalities. On December 9th, 2015, Mexico became the first country for which the dengue vaccine was approved for use. In anticipation of a vaccine rollout, analysis of the cost-effectiveness of the dengue vaccination program that quantifies the dynamics of disease transmission is essential.

Methods

We developed a dynamic transmission model of dengue in Yucatán, Mexico and its proposed vaccination program to incorporate herd immunity into our analysis of cost-effectiveness analysis. Our model also incorporates important characteristics of dengue epidemiology, such as clinical cross-immunity and susceptibility enhancement upon secondary infe

SUBMITTER: Shim E 

PROVIDER: S-EPMC5381893 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature