Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.

ABSTRACT: Cognitive decline is a major biomedical challenge as the global population ages. Elevated levels of the longevity factor klotho suppress aging, enhance cognition, and promote synaptic plasticity and neural resilience against aging and Alzheimer's disease (AD)-related pathogenic proteins. Here, we examined the relationship between human genetic variants of KLOTHO and systemic klotho levels - and assessed neuroanatomic correlates of serum klotho in a cohort of healthy older adults. Serum klotho levels were increased with KL-VS heterozygosity, as anticipated. We report, for the first time, that serum klotho levels were paradoxically decreased with KL-VS homozygosity. Further, we found that higher serum klotho levels were associated with measures of greater intrinsic connectivity in key functi

SUBMITTER: Yokoyama JS 

PROVIDER: S-EPMC5382127 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature