Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence?

ABSTRACT:

Objectives

Alcohol dependence represents a leading cause of mortality and morbidity. Understanding the variables that contribute to this diagnosis and its severity is critical. An overlap between factors that may predispose people to become obese and those that may increase the risk of alcohol dependence may exist. However, data in the literature are not conclusive. Therefore, this study aimed to identify the association between alcohol dependence and obesity-related factors, including biochemical and genetic factors.

Methods

In a case-control study with 829 participants, factors involved with metabolism and obesity were assessed, including biochemical lipid and liver markers, and the fat mass and obesity-associated (FTO) single nucleotide polymorphism (SNP) rs8050136.

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SUBMITTER: Goodyear K 

PROVIDER: S-EPMC5382351 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature