Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?

ABSTRACT: Metastatic melanoma remains a fatal disease to many worldwide, even after the breakthrough introduction of targeted therapies such as BRAF inhibitors and immune checkpoint blockade therapies such as CTLA-4 and PD-1 inhibitors. With advances in our understanding of this disease, as well as the increasing data gathered from patient studies, the significance of the host immune response to cancer progression and response to treatment is becoming clear. More specifically, the presence of intratumoral CD8⁺ cytotoxic T-cells correlates with better prognosis whereas the accumulation of monocytes/macrophages and neutrophils in the tumour is often associated with worse prognosis. Access and infiltration of circulating leukocytes into the tumour is governed by adhesion molecules and chemok

SUBMITTER: Tan LY 

PROVIDER: S-EPMC5382436 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature