Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats.

ABSTRACT:

Background

Cs₂K₄Na [SiW₉Nb₃O₄₀] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications.

Methods

The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests.

Results

The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, rega

SUBMITTER: Qu X 

PROVIDER: S-EPMC5382445 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature