Maternal urinary phthalates and sex-specific placental mRNA levels in an urban birth cohort.

ABSTRACT:

Background

Prenatal urinary concentrations of phthalates in women participants in an urban birth cohort were associated with outcomes in their children related to neurodevelopment, autoimmune disease risk, and fat mass at 3,5,7, and 8 years of life. Placental biomarkers and outcomes at birth may offer biologic insight into these associations. This is the first study to address these associations with candidate genes from the phthalate and placenta literature, accounting for sex differences, and using absolute quantitation methods for mRNA levels.

Methods

We measured candidate mRNAs in 180 placentas sampled at birth (HSD17B1, AHR, CGA, CYP19A1, SLC27A4, PTGS2, PPARG, CYP11A1) by quantitative PCR and an absolute standard curve. We estimated associations of log_e mRNA

SUBMITTER: Adibi JJ 

PROVIDER: S-EPMC5382502 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature