TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity.

ABSTRACT: Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4',6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy i

SUBMITTER: Seo GY 

PROVIDER: S-EPMC5382558 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature