Crystal structures of three 4-substituted-2,2'-bipyridines synthesized by Sonogashira and Suzuki-Miyaura cross-coupling reactions.

ABSTRACT: Facile synthetic routes for three 4-substituted 2,2'-bi-pyridine derivatives, 4-[2-(4-methyl-phenyl)-ethyn-yl]-2,2'-bi-pyridine, C₁₉H₁₄N₂, (I), 4-[2-(pyridin-3-yl)ethyn-yl]-2,2'-bi-pyridine, C₁₇H₁₁N₃, (II), and 4-(indol-4-yl)-2,2'-bi-pyridine, C₁₈H₁₃N₃, (III), via Sonogashira and Suzuki-Miyaura cross-coupling reactions, respect-ively, are described. As indicated by X-ray analysis, the 2,2'-bi-pyridine core, the ethyl-ene linkage and the substituents of (I) and (II) are almost planar [dihedral angles between the two ring systems: 8.98 (5) and 9.90 (6)° for the two mol-ecules of (I) in the asymmetric unit and 2.66 (14)° for (II)], allowing π-conjugation. On the contrary, in (III), the in

SUBMITTER: Luong Thi Thu T 

PROVIDER: S-EPMC5382633 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature