Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.

ABSTRACT: Alzheimer's disease is characterized by the combined presence of amyloid plaques and tau pathology, the latter being correlated with the progression of clinical symptoms. Neuroinflammatory changes are thought to be major contributors to Alzheimer's disease pathophysiology, even if their precise role still remains largely debated. Notably, to what extent immune responses contribute to cognitive impairments promoted by tau pathology remains poorly understood. To address this question, we took advantage of the THY-Tau22 mouse model that progressively develops hippocampal tau pathology paralleling cognitive deficits and reappraised the interrelationship between tau pathology and brain immune responses. In addition to conventional astroglial and microglial responses, we identified a CD8-positiv

SUBMITTER: Laurent C 

PROVIDER: S-EPMC5382942 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature