The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease.

ABSTRACT: Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches. Here we test the hypothesis that such differences arise through differential effects on the temporal dynamics of beta activ

SUBMITTER: Tinkhauser G 

PROVIDER: S-EPMC5382944 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature