Associations between body mass index-related genetic variants and adult body composition: The Fenland cohort study.

ABSTRACT:

Background/objective

Body mass index (BMI) is a surrogate measure of adiposity but does not distinguish fat from lean or bone mass. The genetic determinants of BMI are thought to predominantly influence adiposity but this has not been confirmed. Here we characterise the association between BMI-related genetic variants and body composition in adults.

Subjects/methods

Among 9667 adults aged 29-64 years from the Fenland study, a genetic risk score for BMI (BMI-GRS) was calculated for each individual as the weighted sum of BMI-increasing alleles across 96 reported BMI-related variants. Associations between the BMI-GRS and body composition, estimated by dual-energy X-ray absorptiometry (DXA) scans, were examined using age-adjusted linear regression models, separately by sex.

R

SUBMITTER: Clifton EA 

PROVIDER: S-EPMC5382973 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature