Characterization of the resting-state brain network topology in the 6-hydroxydopamine rat model of Parkinson's disease.

ABSTRACT: Resting-state functional MRI (rsfMRI) is an imaging technology that has recently gained attention for its ability to detect disruptions in functional brain networks in humans, including in patients with Parkinson's disease (PD), revealing early and widespread brain network abnormalities. This methodology is now readily applicable to experimental animals offering new possibilities for cross-species translational imaging. In this context, we herein describe the application of rsfMRI to the unilaterally-lesioned 6-hydroxydopamine (6-OHDA) rat, a robust experimental model of the dopamine depletion implicated in PD. Using graph theory to analyse the rsfMRI data, we were able to provide meaningful and translatable measures of integrity, influence and segregation of the underlying functional brai

SUBMITTER: Westphal R 

PROVIDER: S-EPMC5382982 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature