Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy.

ABSTRACT: At present, it has become evident that inflammation plays a critical role in tumor growth; meanwhile, chemotherapeutic agents using nanocarriers have been suggested as a promising strategy in cancer treatment. In this study, novel redox-responsive micelles were prepared from monomethoxy-poly(ethylene glycol)-chitosan-S-S-hexadecyl (C₁₆-SS-CS-mPEG). These micelles were able to carry and deliver drugs into tumor cells. To serve as a control, monomethoxy-poly(ethylene glycol)-chitosan-C-C-hexadecyl (C₁₆-CC-CS-mPEG) was developed in a similar fashion to that used to yield C₁₆-CC-CS-mPEG without a redox-responsive disulfide bond. The cellular uptake mechanisms of both micelles were determined. The efficient intracellular drug release from micelles in MCF-7 cells

SUBMITTER: Zhao S 

PROVIDER: S-EPMC5383081 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature