Phloridzin inhibits high K⁺-induced contraction via the inhibition of sodium: glucose cotransporter 1 in rat ileum.

ABSTRACT: Recent studies have shown that phloridzin, an inhibitor of sodium-glucose cotransporter (SGLT), strongly decreases high K⁺-induced contraction in phasic muscle, such as tenia coli, but slightly affects tonic muscle, such as trachea . In this study, we examined the inhibitory mechanism of phloridzin on high K⁺-induced muscle contraction in rat ileum, a phasic muscle. Phloridzin inhibited the high K⁺-induced contraction in the ileum and the aorta, and the relaxing effect of phloridzin at 1 mM in the ileum was approximately five-fold more potent than that in the aorta. The expression of SGLT1 mRNA in the ileum was higher than that of the aorta. Phloridzin significantly inhibited NADH/NAD ratio and phosphocreatine (PCr) content in the ileum; however, applicatio

SUBMITTER: Kanda H 

PROVIDER: S-EPMC5383183 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature