Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance.

ABSTRACT:

Background

Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs). Many of the OSCCs present at late stages with an exceptionally poor prognosis. A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis thereby resulting in an inability to deliver targeted therapy.

Objectives

The current study aimed to identify copy number alterations (CNAs) in OSCC using array comparative genomic hybridization (array CGH) and to correlate the CNAs with clinico-pathologic parameters and clinical outcomes.

Materials and methods

Using array CGH, genome-wide profiling was performed on 75 OSCCs. Selected genes that were harboured in the freq

SUBMITTER: Vincent-Chong VK 

PROVIDER: S-EPMC5383235 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature