Risk of second primary malignancies among patients with prostate cancer: A population-based cohort study.

ABSTRACT:

Purpose

The rising incidence and life expectancy associated with prostate cancer (PCa) has led to increasing interest in predicting the risk of second primary malignancies (SPMs) among PCa survivors, although data regarding SPMs after PCa are controversial.

Methods

We identified 30,964 patients from the National Health Insurance Research Database in Taiwan who had newly diagnosed PCa between 2000 and 2010. Each patient was randomly frequency-matched with an individual without PCa, based on age, comorbidity, and index year. Competing-risks regression models were used to estimate subhazard ratios (SHRs) of SPMs development associated with PCa. The Bonferroni adjustment was used in multiple comparisons.

Results

Men with PCa had a trend of lower risk of developing overall

SUBMITTER: Fan CY 

PROVIDER: S-EPMC5383246 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature