SAMHD1 is a barrier to antimetabolite-based cancer therapies.
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ABSTRACT:
SUBMITTER: Rudd SG
PROVIDER: S-EPMC5383367 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
SAMHD1 is a barrier to antimetabolite-based cancer therapies.
Rudd Sean G SG Schaller Torsten T Herold Nikolas N
Molecular & cellular oncology 20170203 2
The outcome of acute myelogenous leukemia (AML) therapy depends on the propensity of leukemic blasts to accumulate ara-CTP, the active triphosphate of cytarabine (ara-C). We identified sterile α motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity. Therefore, we propose targeting SAMHD1 as a strategy to potentiate cytarabine and possibly other antimetabolite-based therapies. ...[more]
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