Role of circulating factors in cardiac aging.

ABSTRACT: Worldwide increase in life expectancy is a major contributor to the epidemic of chronic degenerative diseases. Aging, indeed, simultaneously affects multiple organ systems, and it has been hypothesized that systemic alterations in regulators of tissue physiology may regulate this process. Cardiac aging itself is a major risk factor for cardiovascular diseases and, because of the intimate relationship with the brain, may contribute to increase the risk of neurodegenerative disorders. Blood-borne factors may play a major role in this complex and still elusive process. A number of studies, mainly based on the revival of parabiosis, a surgical technique very popular during the 70s of the 20^th century to study the effect of a shared circulation in two animals, have indeed shown the p

SUBMITTER: Cannata A 

PROVIDER: S-EPMC5383555 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature