Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?

ABSTRACT: Bridging the gaps between experimental systems on different hierarchical scales is needed to overcome remaining challenges in the understanding of muscle contraction. Here, a mathematical model with well-characterized structural and biochemical actomyosin states is developed to that end. We hypothesize that this model accounts for generation of force and motion from single motor molecules to the large ensembles of muscle. In partial support of this idea, a wide range of contractile phenomena are reproduced without the need to invoke cooperative interactions or ad hoc states/transitions. However, remaining limitations exist, associated with ambiguities in available data for model definition e.g.: (1) the affinity of weakly bound cross-bridges, (2) the characteristics of the cross-bridge ela

SUBMITTER: Mansson A 

PROVIDER: S-EPMC5383694 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature