FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

ABSTRACT: FZR1 (fizzy-related protein homolog; also known as CDH1 [cell division cycle 20 related 1]) functions in the cell cycle as a specific activator of anaphase-promoting complex or cyclosome ubiquitin ligase, regulating late mitosis, G₁ phase, and activation of the G₂-M checkpoint. FZR1 has been implicated as both a tumor suppressor and oncoprotein, and its precise contribution to carcinogenesis remains unclear. Here, we examined the role of FZR1 in tumorigenesis and cancer therapy by analyzing tumor models and patient specimens. In an Fzr1 gene-trap mouse model of B-cell acute lymphoblastic leukemia (B-ALL), mice with Fzr1-deficient B-ALL survived longer than those with Fzr1-intact disease, and sensitivity of Fzr1-deficient B-ALL cells to DNA

SUBMITTER: Ishizawa J 

PROVIDER: S-EPMC5383867 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature