Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer.

ABSTRACT:

Background

Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this study, we focused on the evaluation of the transcription factor Six1 (Sine oculis 1). This protein is involved in embryologic development and its contribution to carcinogenesis has been described in several studies.

Methods

Immunohistochemistry against Six1 was performed on a tissue microarray containing specimens of primary pancreatic ductal adenocarcinomas (PDAC) of 139 patients. Nuclear and cytoplasmic expression was evaluated and correlated to histopathological parameters. Expression of Six1 was inhibited t

SUBMITTER: Lerbs T 

PROVIDER: S-EPMC5383957 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature