Genome-Wide Methylation Analysis Identifies Specific Epigenetic Marks In Severely Obese Children.

ABSTRACT: Obesity is a heterogeneous disease with many different subtypes. Epigenetics could contribute to these differences. The aim of this study was to investigate genome-wide DNA methylation searching for methylation marks associated with obesity in children and adolescents. We studied DNA methylation profiles in whole blood cells from 40 obese children and controls using Illumina Infinium HumanMethylation450 BeadChips. After correction for cell heterogeneity and multiple tests, we found that compared to lean controls, 31 CpGs are differentially methylated in obese patients. A greatest proportion of these CpGs is hypermethylated in obesity and located in CpG shores regions. We next focused on severely obese children and identified 151 differentially methylated CpGs among which 10 with a differen

SUBMITTER: Fradin D 

PROVIDER: S-EPMC5384222 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature