Ontology highlight
ABSTRACT:
SUBMITTER: Keightley MC
PROVIDER: S-EPMC5384227 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nature communications 20170406
In response to infection and injury, the neutrophil population rapidly expands and then quickly re-establishes the basal state when inflammation resolves. The exact pathways governing neutrophil/macrophage lineage outputs from a common granulocyte-macrophage progenitor are still not completely understood. From a forward genetic screen in zebrafish, we identify the transcriptional repressor, ZBTB11, as critical for basal and emergency granulopoiesis. ZBTB11 sits in a pathway directly downstream o ...[more]