Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3⁺ regulatory T cells in murine colon cancer.

ABSTRACT: The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting. We have identified a genetically and functionally distinct subset of dynamic bone marrow myeloid cells that are characterized by histidine decarboxylase (HDC) expression. Lineage tracing in Hdc-CreERT2;R26-LSL-tdTomato mice revealed that in homeostasis, there is a strong bias by HDC⁺ myeloid cells toward the CD11b⁺Ly6G^hi granulocytic lineage, which was accelerated during azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colonic carcinogenesis. More importantly, HDC⁺ myeloid cells strongly promoted colonic tumorigenesis, and colon tumor progression w

SUBMITTER: Chen X 

PROVIDER: S-EPMC5384347 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature