Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.

ABSTRACT: Evidence suggests that activation of autophagy in neoplastic cells potentiates antitumor immunity through cross-presentation of tumor-associated antigens to T cells and release of immune mediators. The SQSTM1 (sequestosome 1, p62) protein is degraded by activated autophagy, and might enhance immune response to tumor cells. We hypothesized that tumor SQSTM1 expression level might be inversely associated with T-cell densities in colorectal carcinoma tissue. We evaluated tumor SQSTM1 expression by immunohistochemistry in 601 rectal and colon cancer cases within the Nurses' Health Study and Health Professionals Follow-up Study. Ordinal logistic regression analyses were conducted to assess the association of tumor SQSTM1 expression with CD3⁺, CD8⁺, CD45RO (PTPRC)⁺

SUBMITTER: Kosumi K 

PROVIDER: S-EPMC5384412 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature