A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery.

ABSTRACT: Gold(iii) porphyrin-PEG conjugates [Au(TPP-COO-PEG₅₀₀₀-OCH₃)]Cl (1) and [Au(TPP-CONH-PEG₅₀₀₀-OCH₃)]Cl (2) have been synthesized and characterized. Based on the amphiphilic character of the conjugates, they were found to undergo self-assembly into nanostructures with size 120-200 nm and this did not require the presence of other surfactants or components for nano-assembly, unlike most conventional drug nano-formulations. With a readily hydrolyzable ester linkage, chemotherapeutic [Au(TPP-COOH)]⁺ exhibited triggered release from the conjugate 1 in acidic buffer solution as well as in vitro and in vivo without the formation of toxic side products. The nanostructures of 1 showed higher cellular upt

SUBMITTER: Chung CY 

PROVIDER: S-EPMC5384453 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature