Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid.

ABSTRACT:

Background

Maleic acid is a multi-functional chemical widely used in the field of industrial chemistry for producing food additives and food contact materials. As maleic acid may contaminate food by the release from food packages or intentional addition, it raises the concern about the effects of excessive dietary exposure to maleic acid on human health. However, the influence of maleic acid on human health has not been thoroughly studied. In silico toxicogenomics approaches have found the association between maleic acid and nervous system disease in human. The aim of this study is to experimentally explore the effects of maleic acid on human neuronal cells.

Methods

A microarray-based transcriptome profiling was performed to offer a better understanding of the effects of mal

SUBMITTER: Wang CC 

PROVIDER: S-EPMC5384566 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature