Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.

ABSTRACT: Melanoma is cancer of melanin-containing melanocyte cells. This neoplasm is one of the most deadly forms of skin cancer, and currently available therapeutic options are insufficient in significantly improve outcomes for many patients. Therefore, novel targets are required to effectively manage this neoplasm. Several sirtuins have previously been found to be upregulated in melanoma, so in this study, the expression profile of SIRT2 was determined. Employing a tissue microarray containing benign nevi, primary melanomas, and lymph node metastases, we have found that the tissue from lymph node metastases appears to have a significant upregulation of SIRT2 relative to primary tumors across the nuclear, cytoplasmic, and whole cell data. Additionally, SIRT2 staining was found to be higher in the

SUBMITTER: Wilking-Busch MJ 

PROVIDER: S-EPMC5384585 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature