Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma.

ABSTRACT:

Objective

Myosin light chain 9 (MYL9) is necessary for cytoskeletal dynamics and experimental metastasis, but its expression in esophageal squamous cell carcinoma (ESCC) has not been addressed. We investigated the expression pattern and clinical significance of MYL9 in patients with ESCC.

Methods

We examined MYL9 expression using quantitative real-time PCR and western blotting in NE1 immortalized esophageal epithelial cells, ESCC cell lines, and paired ESCC tissues. MYL9 protein in 136 primary ESCC tissues and other types of solid tumor was detected using immunohistochemistry. The association between MYL9 expression and clinical parameters and survival was evaluated by statistical analysis.

Results

MYL9 was significantly upregulated in the ESCC cell lines as compared

SUBMITTER: Wang JH 

PROVIDER: S-EPMC5384754 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature