Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis.

ABSTRACT: During meiotic prophase, a structure called the synaptonemal complex (SC) assembles at the interface between aligned pairs of homologous chromosomes, and crossover recombination events occur between their DNA molecules. Here we investigate the inter-relationships between these two hallmark features of the meiotic program in the nematode C. elegans, revealing dynamic properties of the SC that are modulated by recombination. We demonstrate that the SC incorporates new subunits and switches from a more highly dynamic/labile state to a more stable state as germ cells progress through the pachytene stage of meiotic prophase. We further show that the more dynamic state of the SC is prolonged in mutants where meiotic recombination is impaired. Moreover, in meiotic mutants where recombination inte

SUBMITTER: Pattabiraman D 

PROVIDER: S-EPMC5384771 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature