Investigations in GABA_A receptor antibody-associated encephalitis.

ABSTRACT:

Objective

To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABA_A receptor (GABA_AR) encephalitis.

Methods

Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABA_AR were determined using reported techniques.

Results

Patients' median age was 40.5 years (interquartile range 48.5 [13.75-62.35] years; the youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration of cognition (67%), behavior (46%), consciousness (42%), or abnormal movements (35%). Comorbidities were identified in 11 (42%) patients, including 7 tumors (mostly thymomas), 2 herpesvirus encephali

SUBMITTER: Spatola M 

PROVIDER: S-EPMC5384834 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature