Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study.

ABSTRACT:

Objective

To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD).

Methods

Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Province starting in 1989 until 2009, every 5th year. Register-based information on HT prescriptions was available since 1995. Probable AD cases, based on DSM-IV and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria, were identified from the special reimbursement register (1999-2009). The study population included 8,195 women (227 cases of incident AD).

Results

Postmenopa

SUBMITTER: Imtiaz B 

PROVIDER: S-EPMC5384835 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature