Clinicopathological features and clinical outcomes associated with TP53 and BRAF^Non-V600 mutations in cutaneous melanoma patients.

ABSTRACT:

Background

BRAF^V600 , NRAS, TP53, and BRAF^Non-V600 are among the most common mutations detected in non-acral cutaneous melanoma patients. Although several studies have identified clinical and pathological features associated with BRAF^V600 and NRAS mutations, limited data are available regarding the correlates and significance of TP53 and BRAF^Non-V600 mutations.

Methods

This study analyzed the patient demographics, primary tumor features, and clinical outcomes of a large cohort of non-acral cutaneous melanoma patients who had undergone clinically indicated molecular testing (n = 926).

Results

The prevalence of BRAF^V600 , NRAS, TP53, and BRAF^Non-V600 mutations was 43%, 21%, 19%, and 7%, respectively. The

SUBMITTER: Kim DW 

PROVIDER: S-EPMC5384865 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature