GRMD cardiac and skeletal muscle metabolism gene profiles are distinct.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, which codes for the dystrophin protein. While progress has been made in defining the molecular basis and pathogenesis of DMD, major gaps remain in understanding mechanisms that contribute to the marked delay in cardiac compared to skeletal muscle dysfunction.

Methods

To address this question, we analyzed cardiac and skeletal muscle tissue microarrays from golden retriever muscular dystrophy (GRMD) dogs, a genetically and clinically homologous model for DMD. A total of 15 dogs, 3 each GRMD and controls at 6 and 12 months plus 3 older (47-93 months) GRMD dogs, were assessed.

Results

GRMD dogs exhibited tissue- and age-specific transcriptional profiles and enriched functions in skeletal

SUBMITTER: Markham LW 

PROVIDER: S-EPMC5385041 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature