Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep.

ABSTRACT:

Background

In farm animals, mitochondrial DNA (mtDNA) effect on economic performance remains hot-topic for breeding and genetic selection. Here, 53 maternal lineages of Small-tailed Han sheep were used to investigate the association of mitochondrial DNA variations and the lambing litter size.

Results

Sequence sweeping of the mitochondrial coding regions discovered 31 non-synonymous mutations, and the association study revealed that T7719G in mtDNA tRNA-Lys gene was associated with litter size (P < 0.05), manifesting 0.29 lambs per litter between the G and T carriers. Furthermore, using the mixed linear model, we assayed the potential association of the ovine litter size and haplogroups and multiple-level mtDNA haplotypes, including general haplotypes, assembled

SUBMITTER: Chen X 

PROVIDER: S-EPMC5385064 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature