High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice.

ABSTRACT:

Background

It is well known that the microbiota of high-fat (HF) diet-induced obese mice differs from that of lean mice, but to what extent, this difference reflects the obese state or the diet is unclear. To dissociate changes in the gut microbiota associated with high HF feeding from those associated with obesity, we took advantage of the different susceptibility of C57BL/6JBomTac (BL6) and 129S6/SvEvTac (Sv129) mice to diet-induced obesity and of their different responses to inhibition of cyclooxygenase (COX) activity, where inhibition of COX activity in BL6 mice prevents HF diet-induced obesity, but in Sv129 mice accentuates obesity.

Results

Using HiSeq-based whole genome sequencing, we identified taxonomic and functional differences in the gut microbiota of the two mous

SUBMITTER: Xiao L 

PROVIDER: S-EPMC5385073 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature