Development and validation of a prognostic score during tuberculosis treatment.

ABSTRACT:

Background

Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas.

Methods

We used data for patients aged ≥15 years, diagnosed and treated for tuberculosis at the Yaounde Jamot Hospital between January 2012 and December 2013. Baseline characteristics associated with mortality were investigated using logistic regressions. A simple prognosis score (CABI) was constructed with regression coefficients for predictors in the final model. Internal validation used bootstrap resampling procedures. Models discrimination was assessed using c-statistics and calibration assessed via calibration plots and the Hosmer and Lemeshwow (H-L) statistics. The

SUBMITTER: Pefura-Yone EW 

PROVIDER: S-EPMC5385091 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature