Single swim sessions in C. elegans induce key features of mammalian exercise.

ABSTRACT:

Background

Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedentary and the aging populations. Still, how exercised muscle signals to induce system-wide health improvement remains poorly understood. With a long-term interest in interventions that promote animal-wide health improvement, we sought to define exercise options for Caenorhabditis elegans.

Results

Here, we report on the impact of single swim sessions on C. elegans physiology. We used microcalorimetry to show that C. elegans swimming has a greater energy cost than crawling. Animals that swam continuously for 90 min specifically consumed muscle fat supplies and ex

SUBMITTER: Laranjeiro R 

PROVIDER: S-EPMC5385602 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature