Blocking the recruitment of naive CD4⁺ T cells reverses immunosuppression in breast cancer.

ABSTRACT: The origin of tumor-infiltrating Tregs, critical mediators of tumor immunosuppression, is unclear. Here, we show that tumor-infiltrating naive CD4⁺ T cells and Tregs in human breast cancer have overlapping TCR repertoires, while hardly overlap with circulating Tregs, suggesting that intratumoral Tregs mainly develop from naive T cells in situ rather than from recruited Tregs. Furthermore, the abundance of naive CD4⁺ T cells and Tregs is closely correlated, both indicating poor prognosis for breast cancer patients. Naive CD4⁺ T cells adhere to tumor slices in proportion to the abundance of CCL18-producing macrophages. Moreover, adoptively transferred human naive CD4⁺ T cells infiltrate human breast cancer orthotopic xenografts in a CCL18-dependent

SUBMITTER: Su S 

PROVIDER: S-EPMC5385617 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature